Welcome to SPARK!
SPARK (Simple Platform for Agent-based Representation of Knowledge) is a cross-platform, free software for multi-scale agent-based modeling (ABM). Specifically, it provides some unique features for biomedical model development at the systems level. Our goal is to provide a lightweight, convenient, extensible and computationally efficient platform for ABM modelers. SPARK is under continuous development by the team at CIRM at the University of Pittsburgh.
Users Group
infected by Hepatitis C. blue dots - virus; green - HMGB1; red dots - portal triads.
Publications
Solovyev, A., Mikheev, M., Zhou, L., Dutta-Moscato, J., Ziraldo, C., An, G., Vodovotz, Y. and Mi, Q., SPARK: A Framework for Multi-Scale Agent-based Biomedical Modeling, International Journal of Agent Technologies and Systems, 2010, 2(3):18-30.
Dutta-Moscato, J.; Solovyev, A.; Mi, Q.; Nishikawa, T.; Soto-Gutierrez, A.; Fox, I.; Vodovotz, Y. A multiscale agent-based model of liver fibrosis progression. Frontiers Bioeng. Biotechnol. 2014. 2: Article 18.
Ziraldo, C.; Solovyev, A.; Allegretti, A.; n, S.; Henzel, M.K.; Sowa, G.A.; Brienza, D.; An, G.; Mi, Q.; Vodovotz, Y. A Computational, tissue-realistic model of pressure ulcer formation in individuals with spinal cord injury. PLoS Comp. Biol. 2015. 11:e1004309.
Development Team
Project Leader: Qi Mi
Author: Alexey Solovyev
Developers: Alexy Solovyey, Maxim Mikheev, Qi Mi
Project Members: Leming Zhou, Joyeeta Dutta-Moscato, Cordelia Ziraldo, Gary An
CIRM Director: Prof. Yoram Vodovotz